Wnt Signalling: A Moving Picture Emerges From van gogh
نویسندگان
چکیده
Recent studies on vertebrate homologues of the van gogh/strabismus (vang/stbm) gene, a key player in planar cell polarity signalling in Drosophila, show that vang/stbm is involved in patterning and morphogenesis during vertebrate gastrulation where it modulates two distinct Wnt signals.
منابع مشابه
Wnt Signalling: Refocusing on Strabismus
Vertebrate homologues of the Strabismus/van Gogh (stbm/vang) gene have been implicated in patterning and morphogenesis during gastrulation. Recent work shows that stbm/vang is mutated in zebrafish trilobite mutants and that stbm/vang is required for morphogenesis but not patterning during zebrafish gastrulation.
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Mutations in the Van Gogh gene result in the altered polarity of adult Drosophila cuticular structures. On the wing, Van Gogh mutations cause an altered polarity pattern that is typical of mutations that inactivate the frizzled signaling/signal transduction pathway. The phenotype however, differs from those seen previously, as the number of wing cells forming more than one hair is intermediate ...
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متن کاملVan Gogh's Physician
On December 24, 1888, a patient was admitted to the Hotel Dieu Hospital in Arles, France, brought in by the police because of reports that he had cut off his ear and given it to a woman. The patient was the Dutch painter, Vincent Van Gogh. The doctor on call was Dr. Felix Rey, a young “interne en medicine,” age 21 (Figure 1). Van Gogh had mutilated the lower part of his ear. Dr. Rey had earlier...
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Whether Van Gogh (1853–1890) had epilepsy has been subject to doubt and conjecture in the fields of art and medicine. Even epileptologists have had divergent views. Gastaut admitted that Van Gogh had epilepsy, but considered that his seizures were triggered by alcohol [1–3], whereas according to Hughes, Van Gogh more likely suffered from fainting fits [4]. The recent edition of Van Gogh's corre...
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ورودعنوان ژورنال:
- Current Biology
دوره 12 شماره
صفحات -
تاریخ انتشار 2002